DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by using 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal buildings of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated https://rolimi788rmg4.rimmablog.com/profile